The key to the treatment of obese diabetics is to relieve insulin resistance

Diabetes article list

2014-09-21 39 Health Net

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Core Tip: As we all know, there are two main causes of type 2 diabetes, namely insulin resistance and islet function defects (insulin secretion deficiency). The so-called insulin resistance is that the body is not sensitive to insulin. Most patients with insulin resistance are obese.

Diabetes is divided into type I diabetes and type 2 diabetes. Among them, type I diabetes occurs mostly in adolescents, and its insulin secretion is lacking. It must rely on insulin therapy to maintain life. Type II diabetes is more common in middle-aged and elderly people after the age of 30. The amount of insulin secreted is not low or even high. The cause is mainly that the body is not sensitive to insulin (ie, insulin resistance).

Insulin resistance type 2 sugar human nemesis

It is well known that there are two main causes of type 2 diabetes, namely insulin resistance and islet function deficit (insulin secretion deficiency). The so-called insulin resistance is that the body is not sensitive to insulin. Most patients with insulin resistance are obese , which is related to the increase of fat cell volume and relative decrease of insulin receptor in obese people, which is related to the decreased sensitivity of insulin target organs such as liver, muscle and fat to insulin.

Studies have shown that obesity, hyperglycemia , hypertension , and dyslipidemia are interrelated, and it directly promotes a series of health problems such as atherosclerotic cardiovascular disease. Only by fundamentally solving insulin resistance and improving insulin work efficiency, a series of problems such as hyperglycemia, hypertension, and dyslipidemia will be significantly improved.

Many patients with type 2 diabetes have insulin resistance as early as the early stage of diabetes. It is precisely insulin resistance that promotes the development of the disease, because insulin resistance reduces the effectiveness of insulin, and islet β cells have to increase insulin secretion to meet the requirements. The burden on islets is aggravated and the beta cell failure is accelerated.

Sugar human blood sugar is mainly due to insulin resistance

We all know that the only hormone in the human body that can lower blood sugar is insulin secreted by human pancreatic β cells. There are only two reasons for not getting too high blood sugar:

First, the loss of insulin secretion function, the body can not produce insulin itself (type 1 diabetes, accounting for 5-10% of the diabetic population);

Second, insulin deficiency, that is, insulin resistance (type 2 diabetes, accounting for 90-95% of the diabetic population). Recently, a large number of clinical observations at home and abroad have found that most people with type 2 diabetes have normal or even high insulin secretion, but they cannot reduce excessive blood sugar. What is the reason? This is mainly due to the presence of insulin resistance (or reduced insulin sensitivity).

Endocrinologists pointed out that if insulin is lacking, the problem of using sufficient insulin should be solved. If diabetic patients use a relatively large amount of insulin and combine some drugs, the blood sugar still falls short of the ideal standard. The main reason It is insulin resistance in this person.

Experts suggest that the current methods to improve insulin resistance are: 1. Lifestyle intervention: weight loss, making the body mass index BMI less than or close to 24kg/m2. With appropriate exercise, change the diet to reduce calorie intake, quit smoking and not excessive drinking. 2. Choose the right medication. For example, rosiglitazone ( Taro ) can not only improve the sensitivity of body cells to insulin, reduce insulin resistance, but also improve blood pressure and blood lipids, and can protect islet β-cell function.